The Potential Role of Non-Collagen Proteins in Skin Aging
Cartilage oligomeric metric protein is part of the “non-collagen” proteins of the extracellular matrix and interacts with collagen I via fibril associated fibrils XII and XIV was previously only found in cartilage In fibrotic skin such as in localized scleroderma (morphea) wound tissue and exudates of patients with venous ulcers and in the stroma of […]
Saturday, December 13th, 2014The Anti-Aging Effects of Hyaluronic Acid: Beyond Fillers
Age-related changes are due to many factors influencing the structure of the epidermis (texture changes) as well as changes in the dermis (loss of volume). The following study shows the role of hyaluronic acid (HA), BOTH large and small fragments in Epidermal age related skin changes. This study shows that topical application of small HA […]
Friday, October 10th, 2014Fighting Skin Aging by Targeting the Degradation of Collagen by Collagenase
Skin aging (ageing) concerns the skin, in the epidermis where it is responsible for texture changes. However the most visible effect of aging is loss of volume in the dermis. In the dermis intact collagen fibers (as well as hyaluronic acid) play an important structural role in its volume. The visible changes in aging are […]
Tuesday, September 30th, 2014Photoaging: why “Bad” Collagen builds up.
UV-mediated downregulation of the endocytic collagen receptor, Endo180, contributes to accumulation of extracellular collagen fragments in photoaged skin. Tang S, Lucius R, Wenck H, Gallinat S, Weise JM. J Dermatol Sci. 2013 Apr;70(1):42-8. doi: 10.1016/j.jdermsci.2013.01.008. Epub 2013 Feb 4. Skin aging can be divided into two parts: intrinsic aging or the passing of years. Nothing […]
Tuesday, April 8th, 2014The Role of Periostin in Aging
The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging. Egbert M1, Ruetze M2, Sattler M1, Wenck H1, Gallinat S1, Lucius R3, Weise JM4. J Dermatol Sci. 2014 Jan;73(1):40-8. doi: 10.1016/j.jdermsci.2013.08.010. Epub 2013 Sep 3. Skin aging can be seen: on the epidermis by changes in texture and color. in […]
Thursday, March 20th, 2014Photodynamic Therapy (PDT) To Treat Photoaging (For Professionals)
Introduction PDT is commonly used in actininc keratosis (AK), basal cell carcinoma (BCC), squamous cell carcinoma (SCC), Bowen’s disease and acne vulgaris. The study enrolled 30 patients (5men, 25women) Metvix (methy-aminolelulinic acid) (Galderma) was applied 3 hours under occlusion before light application Aktilite 37J/cm2 (Galderma). 90 days after the procedure: the patients were clinically evaluated, […]
Saturday, March 2nd, 2013Radiofrequency to Treat Photoaging
Radiofrequency facial rejuvenation: evidence-based effect. el-Domyati M, el-Ammawi TS, Medhat W, Moawad O, Brennan D, Mahoney MG, Uitto J. J Am Acad Dermatol. 2011 Mar;64(3):524-35. Lots of electric and laser based devices are promoted as being efficient in rejuvenation. This Egyptian prospective study shows clinically and histologically in a tentatively scientific manner an effect for […]
Sunday, January 1st, 2012Ageing (Aging): Observations and Solutions (For professionals)
Ageing (Aging): Observations and Solutions (For professionals) “With advancing age, skin functions deteriorate due to structural and morphologic changes. In particular, changes in skin barrier integrity, immune function, and nervous system occur, resulting in an incresaed prevalence of certain diseases. As the elderly population is rapidly increasing throughout the world, awareness of these diseases and […]
Monday, July 25th, 2011Role Of The Microfibrills of Fibrillin In Aging (Ageing) And Photoaging (Photoageing) (Sun-induced Ageing) (For Professionals)
Role Of The Microfibrills of Fibrillin In Aging (Ageing) And Photoaging (Photoageing) (Sun-induced Ageing) (For Professionals) Presentation of fibrillin is an extracellular protein is responsible as scafolding for deposition elastic fibres exists as fibrillin f1 and 2 encoded by FBN1 and 2 encoding Marfan syndrome Functions of fibrillin: strengthens elastic fibres and enables transmission of […]
Thursday, May 26th, 2011What’s New In The Pathogenesis And Prevention Of Extrinsic Aging (Ageing) (Photoaging) (For Professionals)
What’s New In The Pathogenesis And Prevention Of Extrinsic Aging (Ageing) (Photoaging) (For Professionals) Photoaging (Extrinsic Aging, solar elastosis) Skin Aging can be Understood by considering two concepts Cumulative acute stress through chronic mechanisms: three stages degeneration of macromolecules Altered cell function Modified Structure and function of organs Mt (mitochondrial) DNA mutation: increased oxidative stress […]
Tuesday, May 24th, 2011
