Pigmentation, Hyperpigmentation and Solutions

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Rhododenol

Tuesday, July 30th, 2013




Rhododenol is also called 4-(4-hydroxyphenyl)-2-butanol. It is manufactured by Kanebo cosmetics and has been on the market since 2008. It is naturally produced and has been approved for the management of pigmentary problems (Melasma, Sun spots, Lentigo…) It is a phenolic compound therefore it is potentially melanocytoxic. It acts by reducing the activity of tyrosinase […]

Skin colour measurement

Wednesday, August 29th, 2012




A few devices exist for the measurement of skin colour. These devices are generally called skin colorimeters. The most well-known existing colorimeters are Chromameter, Mexameter, and the newly developed device DermaCatch. Skin colorimeters are usually equipped with a handpiece which is put on the desired area of the skin and emits certain wavelenghts on the […]

DERMACATCH – The latest advancement in skin colour measurement

Wednesday, August 29th, 2012




Precise skin color (colour) measurement is of the utmost importance for researchers as well as clinicians involved in the field of skin pigmentation. Skin colorimetry has proved to be a delicate and rather complex issue.  This complexity results from several facts: Skin erythema, which readily changes due to internal or external factors, can highly interfere […]

Kojic acid

Wednesday, March 21st, 2012




Kojic acid It is a fungal metabolite which inhibits the enzyme tyrosinase. It binds to copper which becomes unusable by melanocytes. It is used at a concentration of 1% Its therapeutical effets are weak to moderate. Contributors: Dr Christophe HSU – dermatologist. Geneva, Switzerland Bibliography: Katsambas A. Melasma: Pathogenesis and Treatment. 70th Annual Meeting of […]

Hydroquinone (HQ)

Wednesday, March 21st, 2012




Hydroquinone (HQ) Mechanism of action: hydroquinone inhibits activated tyrosinase activity (therefore it does not act on normal skin). A word on available concentrations: 2%: often ineffective 3-5%: good bleaching agent 6-10%: higher concentrations can cause irritation Side effects: Contact dermatitis (Both Allergic and Irritant) Nail Discoloration Exogenous Ochrnosis can rarely occur in dark skin individuals […]

L-ascorbic acid (Vitamin C)

Tuesday, March 20th, 2012




L-ascorbic acid (Vitamin C) Is an antioxidant Is used in the treatment of disorders of pigmentation including melasma (chloasma) (pregnancy mask) Alters the color of melanin from jet black to light tan Unstable as quickly oxidized Bibliography: Katsambas A (Conflicts of Interest: Abbott, Janssen-Cilag, Leo Pharma, Merck, Schering-Plough). Melasma: Pathogenesis and Treatment. 70e Réunion annuelle […]

New Depigmenting substances

Monday, February 20th, 2012




New Depigmenting substances: N-acetyl glucosamine Artocarpanone 4-n-butylresorcinol (rucinol) Ursolic Acid Anthraquinones Cinnamic Acid Macelignan Gallic Acid Glycine Isopanduratin A and 4-Hydroxypanduratin A Kurarinol, Kurarinidol and Trifolirhizin Pycnogenol 8% topical indomethacin cream Selina dien-8-one Taxifolin DeoxyArbutin and its second generation derivatives Hydroperoxy Traxastane t; type Triterpene Piceatannol Handog E. Brown Spots: Melasma Updates.2012 (02) – 20th […]

Existing Depigmenting substances

Monday, February 20th, 2012




They act through: Tyrosinase Inhibition Inhibitors of Inflammation-induced Melanogenic Response Peroxidase inhibition Product Reduction and ROS (Radical Oxygen Scavengers)   Tyrosinase inhibition hydroquinone 4-hydroxyanisole 4-S-CAP and derivatives Arbutin Aloesin Azelaic Acid Kojic Acid Ellagic Acid Resveratrol Oxyeresveratrol Licorice Extract Lactic Acid   Inhibitors of Inflammation Induced Melanogenic Response Chamomille Corticosteroids Gliabridin Tranexamic Acid   Peroxidase […]

Pigmentation by Melanin and Skin Color (Colour)

Tuesday, November 16th, 2010




In humans, melanin pigments are responsible for the visible color of the skin, hair and eyes. Although the blood within the dermis and exogenous pigments as carotenoids may play a role in producing different skin hues, variations in skin pigmentation between different ethnic groups (namely Negroid, Asian and Caucasians) is primarily determined by the amount […]

4-Hydroxyanisole (4-OHA)

Monday, November 15th, 2010




4-OHA is a skin depigmenting agent with moderate efficacy and may be used for the treatment of hyperpigmentary disorders such as melasma and freckles. This agent decreases the number of melanin producing cells in the skin and can whiten the skin to a considerable degree. However, one should be aware of possible side effects such […]

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