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Possible involvement of the dermis in the pathogenesis of vitligo (For Professionals)
Thursday, June 13th, 2013Vitiligo is characterized by the functional loss of melanocytes which induces the well delineated depigmented characteristic lesions. Anomalies have been detected in: melanocytes (mitochondria…) keratinocytes (altered oxydation status in the mitochondria, vaculolization…) dermis (high level of tenascin expression which explains defective adhesion of the melanocytes) The authors have found similar defects in fibroblast cells in [...]
Validamycin A could inhibit the production of melanin (For Professionals)
Thursday, June 13th, 2013The authors shoe that on computer models, validamycin A induces changes in the protein structure of tyrosinase. Tyrosinase is an enyyme involved in the early phases of melanin synthesis. Hore exactly based on targetted hydroxyl group number: HIS85, HIS244, GLU256, HIS259, and ASN260 of tyrosinase interacted with validamycin A. Comment: the conceptual role of validomycin [...]
Dermatology in Systemic Disease – Table of Contents
Monday, May 27th, 2013Iron Deficiency Anemia (Anaemia) And The Skin Skin lesions in Crohn’s disease (2) Mesothelioma and the Skin Morphea (Localized Scleroderma)
How effective is vaccination against post herpetic neuralgia ? (pain after shingles (herpes zoster))
Saturday, May 18th, 2013Shingles is due to the activation of the herpes zostervirus (HZV) following its reactivation from doral ganglia following chicken pox. It is usually self-limited but after 60 there is a much higher incidence of pain following shingles (post-herpetic neuralgia). The pain can last from months to years afterwards. Incidence of shingles and post herpetic [...]
Pigment Research Using In Vitro Models (For Professionals)
Friday, May 17th, 2013Mattek is a company which produces artificial skin models and the authors show application for pigmentary disorders models such as melasma (chloasma, pregnancy mask) and postinflammatory hyperpigmentation. In the study the authors used MelanoDermTM, which is a three-dimensional tissue culture model of human epidermis that contains normal human melanocytes (NHM) and keratinocytes (NHK). The origin of donors (African [...]
Ceramides (For Professionals)
Thursday, May 16th, 2013Ceramides are part of the 3 main lipid types in the skin: ceramide backbone:long aminoalcohol chain (C16-24)= cer (sphingoid base + fatty acid) 12 types identified cholesterol free fatty acids Roles of lipids in the skin constituents of cell membranes (plasma, cellular organelle) lipid droplets (adipocytes in fat and sequestration of toxic lipids (protection from [...]
Melanoma Risk And Alcohol Consumption (For Professionals)
Wednesday, May 15th, 2013Alcohol consumption is linked to many skin problems (click here for manifestations of alcohol on the skin). However this study brings a new association: Melanoma. In this study using statistics (retrospective) the authors documented 1385 patients with invasive melanoma and 750 patients with melanoma in situ who were all followed for an average of 19 years. [...]
Studying Postinflammatory Hyperpigmentation (PIH) on human skin (For Professionals)
Tuesday, May 14th, 2013Postinflammatory hyperpigmentation (PIH) is a common problem in darker skin types and happens after injury or inflammatory dermatoses such as acne vulgaris. The authors sought to create a reproductible model in humans after inducing PIH on the trunk with trichloracetic acid 35% (TCA 35%) and comparing it with PIH induced by truncal acne. 4 patients [...]
Soy derived products to depigment the skin (For Professionals)
Monday, May 13th, 2013Soy contains antioxydants calles isoflavones. The 2 main ones are genistein and daizedine. In this study, the authors studied 7,3’,4’-Trihydroxyisoflavone (7,3’,4’-THIF), a metabolite of daidzedine would have a depigmenting effect Contrarily to daizedine, 7,3’,4’-THIF inhibits the extracellular and intracellular production of melanin by B16F10 cells (induced by α-melanocyte-stimulating hormone (MSH)) (7,3’,4’-THIF), abolished the expression of [...]
Understanding the Pathways Regulating the Production of Melanin to Conceptualize New Treatments (For Professionals)
Sunday, May 12th, 2013The authors constructed the molecular regulatory network of melanogenesis by focusing on 2 pathways: paracrine factor-mediated signaling pathway Microphthalmia-associated transcription factor-related pathway By reviewing the literature, the authors established a “Boolean network model” that describes the dynamical characteristics of the network: Molecules which would decrease pigmentation: CREB, MITF protein, MITF active, GSK3B, CAMP, AC, PKA, [...]
