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Keanu Reeves and Alopecia Areata

Sunday, April 5th, 2015

Keanu Charles Reeves (born in 1964) is a Canadian actor who has starred in many movies such as Speed, the Matrix Trilogy, and Little Buddha. In this photo (above) of a movie he played in (“I love you to Death” as Marlon James, 1990), circumscribed well-defined non scarring balding patches are seen on the scalp […]

George Bush and Actinic Keratosis

Monday, March 30th, 2015

George Herbert Walker Bush (b.1924), a Republican, served two terms under President of the United States. Once playing a round of golf in Summer 2002, he has caught on photograph with the following lesions. In fact, the lesions are precancerous growths called actinic keratoses. 5-fluorouracil (known as Efudex in the United States) is one treatment […]

Bob Marley and Melanoma

Monday, March 30th, 2015

Bob Marley (; 1945-1981) was a Jamaican singer who participated importantly in the development Reggae and was part part of the cultural “Rastafari” movement He was a big soccer enthusiast and in summer of 1976 he traumatized his right toenail. It was diagnosed as a wound lesion and slowly appeared to be healing. However, such […]

Celgene Corporation ®

Saturday, March 28th, 2015

Otezla (apremilast):  systemic (oral) “small molecule” used in the treatment of psoriasis Note that the list is updated regularly as all pharmaceutical companies and products are not included. This is simply a guide to medications which are known to the authors of the website. Full-indications may not be included and side effects are not mentioned. […]

Novartis Pharmaceuticals ®

Saturday, March 28th, 2015

Cosentyx ® (secukinumab):  biologic medical used in the treatment of psoriasis Lamisil ® (terbinafine): topical and systemic substance used in the treatment of fungal infections Note that the list is updated regularly as all pharmaceutical companies and products are not included. This is simply a guide to medications which are known to the authors of […]

Psoriasis: the role of microRNAs ?

Friday, March 27th, 2015

Introduction This article provides new potential molecular mechanisms providing interesting insights in the understanding of psoriasis. Cytokines and genetic findings constitute part of the findings in psoriasis and these have led to the development of the biologics. The following study talks about MicroRNAs miRNA are RNAs not translated into proteins: their size is between 19-25 […]

Omalizumab (Xolair) for Urticaria Treatment

Tuesday, March 24th, 2015

Omalizumab (Xolair): recombinant humanized monoclonal antibody that binds to the free Immunoglobin IgE (produced byB lymphocytes), more specifically on the C3 domain of the IgE heavy chain complete, it block free IgE. Unlike ordinary anti-IgE antibodies, it does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the […]

Psoriasis Treatment with Biologics

Tuesday, March 24th, 2015

Existing TNF-inhbitors: Adalimumab (Abbott) Infliximab (Janssen Bitotech and other biosimilars (generics) Etanercept (Amgen) Certolizumab (UCB) Il-17 antibodies Secukinumab (Cosentyx, Novartis): dosage: injected 300mg at weeks 0, 1, 2, 3, and 4 then 300mg or 150mg every 4 weeks, the doctor decides ! The price is the same for both doses ! Works in 3 weeks […]

Psoriasis treatment with “small molecules”

Tuesday, March 24th, 2015

Available “small molecules”: Apremilast (Otezla) inhibits phosphodiesterase 4 (PDE4) exhibits anti-inflammatory properties apart from PDE4 action, its complete effects are not fully known but it is known (at the time of writing) that it modulates inflammation by reducing TNF-alpha, Il-2, IFN-gamma, leukotrienes and NO synthases. The effect appears to act through increased intracellular cAMP accumulation […]

Isotretinoin: an extreme effect on Muscular tissue

Sunday, March 22nd, 2015

Severe rhabdomyolysis with Isotretinoin Therapy for Acne (Poster) Philips D et al. AAD 2015 Annual Meeting, San Francisco CA – United States Isotretinoin is  an oral vitamin D derivative most commonly used in the treatment of acne. Common side effects include skin and mucosal dryness, lipid elevations and elevated liver enzymes. According to some, the […]

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