Section : Conference Notes

How is melanin produced ? (melanin is the principal pigment giving to the skin its colour)

How is melanin produced ? (melanin is the principal pigment giving to the skin its colour)

  • Tyrosinase is normally inactive and is produced through the transcription of the tyrosinase gene
  • Glycolization (attachment of a sugar) of tyrosinase activates it. Glycolization is induced by sunlight, irritation, hormones, radicals…
  • Activated tyrosinase then converst the amino acid tyrosine to melanin
  • Melanin is then packaged in melanosomes which are then transfered to the surrounding keratinocytes

Contributors:

Dr Christophe HSU – dermatologist. Geneva, Switzerland

Bibliography: Katsambas A. Melasma: Pathogenesis and Treatment. 70e Réunion annuelle de l’AAD (American Academy of Dermatology) – San Diego, California, United States of America (USA)


Category : Comment la mélanine (pigment principal de la couleur de la peau) est t-elle produite ? - Modifie le 03.21.2012Category : How is melanin produced ? (melanin is the principal pigment giving to the skin its colour) - Modifie le 03.21.2012