Maintaining Youthful Skin: Perhaps a Massage is what Benchmark Research Suggests
- The skin is routinely exposed to mechanical stimuli such as: stretching, contraction, compression, torsion
- Cyclical stretching :
- increases secretion of humoral factors and proteolytic enzymes by activating inflammatory signaling pathways in keratinocytes and fibroblasts
- induces degradation of the extracellular matrix
- …the response to it depends on the nature of the stimulus and its duration
- Methods & Results
- the authors used low intensity cyclical stretching and measured the response of normal human dermal fibroblasts (NHDF) by molecular biological and immunological analyses
- cyclic stretching of 10% at 1Hz was done for 3 hours:
- it induced increased expression of cyclooxygenase 2 (COX2) and matrix metalloproteinase-1 (MMP-1)
- However when done at a lower frequency (1/6 Hz):
- the opposite was found, that is reduced COX2 and MMP1.
- increased levels:
- heat shock protein 47 (specific molecular chaperone)
- tropoelastin, fibulin 5 and TGF Beta binding protein 4 (all three regulators of elastogenesis)
The authors conclude that skin responses could depend on the frequency of mechanical stimulation.
Comment: In this study low frequency small mechanical stretching (such as perhaps in a massage ?) could have positive effects on the skin.
Dr Christophe Hsu – dermatologist. Geneva, Switzerland
Source of information: P03-10 Shingaki K. et al. Different responses to low intensity mechanical stress in normal human dermal fibroblasts. JSID Annual Meeting (Japanese Society of Investigative Dermatology, 日本研究皮膚科学会) 2014 – Osaka, Japan