Psoriasis: the role of microRNAs ?
- This article provides new potential molecular mechanisms providing interesting insights in the understanding of psoriasis.
- Cytokines and genetic findings constitute part of the findings in psoriasis and these have led to the development of the biologics.
- The following study talks about MicroRNAs
- miRNA are RNAs not translated into proteins:
- their size is between 19-25 nucleotides
- more than 10000 miRNA in humans
- they regulate 30% of the coding of genes at the post-transcriptional level
- they are highly conserved in evolution
- they are necessary for functional and dysfunctional physiology of cells
- MicroRNA-146a limits inflammation and T -cell inflammation and miRNA-55 are pro-inflammatory
- In mice (knockouts vs wild-type (WT) the following was found:
- in RNA-146a knockout mice we can find lymph node inflammation (structural disorganization) and psoriatic skin
- increase in miRNA-55 in psoriatic skin
- in MiRNA-146a Knockout mice, there is increased inflammation when topical imiquimod is applied.
- How about checking these findings; not only in psoriasis but also its comorbidities
- These findings provide a « fresh way » of understanding pathophysiological changes in psoriasis which could lead to new targeted therapies.
To read more about MicroRNAs, CLICK HERE
Role of microRNA-146a and miRNA-55 imiquimod induced psoriasis-like skin inflammation. Hawks J. S025 residents and fellows symposium. AAD 2015 Annual Meeting, San Francisco CA – United States