The Potential Role of Non-Collagen Proteins in Skin Aging
Cartilage oligomeric metric protein is part of the “non-collagen” proteins of the extracellular matrix and interacts with collagen I via fibril associated fibrils XII and XIV was previously only found in cartilage In fibrotic skin such as in localized scleroderma (morphea) wound tissue and exudates of patients with venous ulcers and in the stroma of […]
Saturday, December 13th, 2014Fighting Skin Aging by Targeting the Degradation of Collagen by Collagenase
Skin aging (ageing) concerns the skin, in the epidermis where it is responsible for texture changes. However the most visible effect of aging is loss of volume in the dermis. In the dermis intact collagen fibers (as well as hyaluronic acid) play an important structural role in its volume. The visible changes in aging are […]
Tuesday, September 30th, 2014Alcohol (OH) and the Skin – Skin Aging (For professionals)
Skin Aging: due to the partial understanding of the association, we have selected the following article from the scientific literature. Von Wurmb-Schwark N, Ringleb A, Schwark T, Broese T, Weirich S, Schlaefke D, Wegener R, Oehmichen M. The effect of chronic alcohol consumption on mitochondrial DNA mutagenesis in human blood. Mutat Res. 2008 Jan 1;637(1-2):73-9. […]
Monday, July 19th, 2010Rhododenol (Rhododendrol)-induced leukoderma: an objective way to ascertain normalization of the skin
This study suggests an objective way to follow-up of rhododenol-induced vitiligo by skin absorption spectrum analysis A word on Rhododenol (Rhododendrol): Rhododendrol (Rhododenol) is is derived from the white birch tree it inhibits tyrosinase activity and melanin synthesis Vitiligo-like lesions were observed and in march 2014, 14000 cases were reported in Japan alone In this […]
Monday, December 15th, 2014Young Skin or when the Cell Nucleus can communicate with the Cytoplasm (Cytosol)
The nuclear membrane separates the nucleus from the cytosol (cytoplasm) several proteins shape are part of its different layers. its role is to maintain mRNA and protein trafficking Lamin A and C are 2 of the main proteins. Its coding gene LMNA is mutated in the premature aging syndrome called the Hutchinson-Gilford progeria syndrome Progerin […]
Saturday, December 13th, 2014The Anti-Aging Effects of Hyaluronic Acid: Beyond Fillers
Age-related changes are due to many factors influencing the structure of the epidermis (texture changes) as well as changes in the dermis (loss of volume). The following study shows the role of hyaluronic acid (HA), BOTH large and small fragments in Epidermal age related skin changes. This study shows that topical application of small HA […]
Friday, October 10th, 2014Photoaging: why “Bad” Collagen builds up.
UV-mediated downregulation of the endocytic collagen receptor, Endo180, contributes to accumulation of extracellular collagen fragments in photoaged skin. Tang S, Lucius R, Wenck H, Gallinat S, Weise JM. J Dermatol Sci. 2013 Apr;70(1):42-8. doi: 10.1016/j.jdermsci.2013.01.008. Epub 2013 Feb 4. Skin aging can be divided into two parts: intrinsic aging or the passing of years. Nothing […]
Tuesday, April 8th, 2014The Role of Periostin in Aging
The matricellular protein periostin contributes to proper collagen function and is downregulated during skin aging. Egbert M1, Ruetze M2, Sattler M1, Wenck H1, Gallinat S1, Lucius R3, Weise JM4. J Dermatol Sci. 2014 Jan;73(1):40-8. doi: 10.1016/j.jdermsci.2013.08.010. Epub 2013 Sep 3. Skin aging can be seen: on the epidermis by changes in texture and color. in […]
Thursday, March 20th, 2014How Fast are you Ageing ? Test it Easily on the Skin ! (For Professionals)
Concept of the Skin pull test. Pinch the skin on the forearm. Then pull on it. In a young person, the skin goes back to normal within 1 second. In an individual over 50*, it takes 5 seconds or more. This is due to the loss of collagen, elasticity etc… *With a strong exposure to […]
Thursday, April 18th, 2013Smoking and the Skin
-Smoking is a major problem and particularly in young people. In the past years, increased smoking has been observed in young women. -It would be responsible for at least a quarter of all deaths, because of cardiovascular diseases and lung cancer. On the skin, smoking is responsible for the following changes: Premature Aging: the skin […]
Monday, March 4th, 2013
