Section : Articles

Flutamide in the Treatment of Androgenic Alopecia in Women

Prospective cohort study on the effects and tolerability of flutamide in patients with female pattern hair loss.

Paradisi R, Porcu E, Fabbri R, Seracchioli R, Battaglia C, Venturoli S.

Ann Pharmacother. 2011 Apr;45(4):469-75. Epub 2011 Apr 12.
  • For androgenetic alopecia, topical treatment is the mainstay and minoxidil is cumbersone to apply. Of all the combinations, topical 5% minoxidil in foam form seems to be the most efficient product (1).
  • Systemic treatments consisting of cyproterone acetate, spironolactone and finasteride are either controversial and are not always effective.
  • In this prospective study (2) over 4 years of 101 women with androgenetic alopecia (and no hormonal androgenism) were included. Results show around 30% improvement (good patient satisfaction, hepatic toxicity: elevation of transaminases in 4% of patients treated with the high dose, no side effects at lower doses).

(1) Shin HS et al. Efficacy of 5% minoxidil versus combined 5% and 0.01% tretinoin for male pattern hair loss: a randomized, double-blind, comparative clinical trial. Am J Clin Dermatol 2007; 8: 285-90

(2)     Dose of:

         -250mg for the first year (loading dose)

        -125mg for the second year

        -62.5mg thereafter as maintenance dose

Category : Le flutamide dans le traitement de l'alopécie androgénique chez les femmes - Modifie le 07.1.2012