Section : Conference Notes

Poster: Treatment of Periocular Infantile Hemangiomas (Strawberry Nevi) with Topical Beta-Blockers

Poster: Treatment of Periocular Infantile Hemangiomas (Strawberry Nevi) with Topical Beta-Blockers


  • Infantile hemangiomas (IH)(also called Strawberry Nevi) induce a higher risk of ocular amblyopia and the treatment by systemic beta blocking agents induces side-effects. The authors tried to evaluate the efficacy of timolol (a Beta-Blocker) applied topically.
  • The authors did a retrospective study on 11 patients with a total of 12 infantile hemangiomas (IH)(Strawberry Nevi)


  • The results show that in all cases, timolol gel at a concentration of 0.5% stopped the proliferation of IH.
  • In 9 out of 10 cases, the dosage of the applied timolol gel at a concentration of 0.5% was of two applications a day. In one case, the timolol 0.5% was applied once a day. In the remaining 1 case, the timolol gel at a concentration of 0.25% was applied twice a day.
  • The average treated period was 4.8 months and the average follow-up was 2.5 months.
  • The treatment was well tolerated without side-effects.
  • Three cases presented initially with aniso-astigmatism (0.5 to 0.75 diopter of difference). Treatment enables reduction of this difference in two cases. However no improvement was seen in one case.
  • Photos which were taken 1.4 months in average after beginning treatments showed a regression of IH (reduction in size, reduction in colour, reduction in volume or improved opthalmological parameters) with a degree of improvement ranging from 33 to 44% according to two independant reviewers.
  • In the patient who had to IH, the one which was treated had its diameter shrink from 15 to 8mm whereas the non treated one increased from 8 to 18mm in diameter.


  • This treatment seems to suit non-complicated IH, even when deep. It enables to stop their proliferation and speed-up the regression phase. Moreover, topical treatment enables prevention of complications linked to the growth of IH.


Dr Christophe HSU – dermatologist. Geneva, Switzerland

Source of information (French): Piram M et al. Traitement topique des hémangiomes infantiles périoculaires par le timolol gel – CHU Sainte Justine, Montréal, Canada