What’s New in Photodermatology ?

-Polymorphous Light Eruption (PMLE):

-appearance more papular in darker skin

-PML patients are more resistant to UV-induced immunosuppression. Explains the “Hardening Concept”: desentisization treatment with UV light: enables immunotolerance

-Voriconazole (antifungal): has been shown to induce developement of erythema, lentigenes, squamous cell carcinoma and melanoma

–Vemurafenib (BRAF inhibitor used for the treatment of metastatic melanoma): 15-30% of patients develop SCC and Keratoacanthoma (ras mutation induction). After phototesting, it is shown that the UV light implicates is UVA (UVB effect is suppressed)

Keratoacanthoma

Contributors:

Dr Christophe HSU – dermatologist. Geneva, Switzerland

Source of information: Lim H. Advances on Photodermatology. 2012 (02) – 20th Regional Conference of Dermatology (RCD) – Manila, Phillipines