Section : Conference Notes

Role Of The Microfibrills of Fibrillin In Aging (Ageing) And Photoaging (Photoageing) (Sun-induced Ageing) (For Professionals)

Role Of The Microfibrills of Fibrillin In Aging (Ageing) And Photoaging (Photoageing) (Sun-induced Ageing) (For Professionals)

Presentation of fibrillin

  • is an extracellular protein
  • is responsible as scafolding for deposition elastic fibres
  • exists as fibrillin f1 and 2
  • encoded by FBN1 and 2
  • encoding Marfan syndrome

Functions of fibrillin:

  • strengthens elastic fibres and enables transmission of forces between the epidermis and dermis
  • What is elastic tissue = elastin + microfibrills fibers

Elastic tissue differences between age groups 18-30 and over 70

  • Methodology:
  1. with atomic force microscopy to determine distance between microfibrills (of fibrillin) (periodicty 56nm=no strain, more than 100=strained and unable to strap back= loss of elasticity)
  2. With molecular combing, tensile strength to determine distance and elastic potential
  • Results:
  1. Up to 30 years old 0.9% of fibrillin microfibrills are separated by more than 100nm
  2. Over 70 years old this goes up to 18.2 %
  3. on immunohistochemistry buttocks vs photoexposed skin in 7o year old individuals show loss of candelabra structure of fibrillinand also a reduction of fibrillin staining in the papillary dermis

Mechanisms of age-related damage:

  • upgrading MMPs (matrix metalloproteinase)
  • cleavage of proMMP
  • upregulation MMP 2 and 9
  • degradation of microfibrills by UV

By using atomic force and electron microscopy microfibrills of fibrillin respond to  UVB by:

  • increasing diameter
  • becoming more tangled (increased flexion angle)
  • reducing their mass with increasing UV dosage (mass mapping)

UVR exposed fibrillin fibres are therefore:

  • shorter
  • weaker
  • have a reduced mass


  • Over 4 years of nightly application, retinoic acid 0,1% reduces photoaging by reconstituting the fibrillin quantity and candelabra disposition.


Dr Christophe HSU – dermatologist. Geneva, Switzerland

Griffiths C, Aging and Photoaging – 22nd World Congress of Dermatology (WCD) – Seoul, South Korea

Category : acide rétinoïque - Modifie le 05.26.2011Category : fibrillin - Modifie le 05.26.2011Category : fibrilline - Modifie le 05.26.2011Category : retinoic acid - Modifie le 05.26.2011Category : rides - Modifie le 05.26.2011Category : skin aging - Modifie le 05.26.2011Category : vieillissement cutané - Modifie le 05.26.2011Category : wrinkles - Modifie le 05.26.2011