Hyperkeratosis of the Nipple:It Could Also Be An Apocrine Lesion

mardi, août 19th, 2014

Beware when looking at an hyperkeratosis lesion on the nipple and discount it as being a simple eczematous rash. Not only can Paget’s disease be missed but also other lesions such as apocrine tumors such as Syringocystadenoma papilliferum as reported in this case report. For full access to the free article in the Journal of […]

Ipilimumab-induced Sweet’s Syndrome

mardi, août 19th, 2014

Sweet’s syndrome is a neutrophilic dermatosis of unknown etiology which presents as “mountain-like” papulesand is often accompanied by systemic symptoms such as fever, myalgia, asthenia and malaise. The cause is often not found but includes: infections (respiratory, gastrointestinal), autoimmune conditions (lupus, rheumatoid, arthritis), vaccination, neoplasia (solid and non solid), drugs (NSAIDS, cotrimoxazole, antiiotics, carbamazepine…) pregnancy, […]

Vancomycin-induced Neutrophilic Dermatosis

mardi, août 19th, 2014

Vancomycin is an antibiotic used for intravenous treatment of bacterial infections, particularly hospital (nosocomial) acquired ones such as with Methicillin Resistant Staphlococcus Aureus (MRSA) infections, which are resistant to penicillin. Vancomycin is known to create neutropenia but the following case report reports the occurrence of a neutrophilic dermatosis mimicking cryptococcus. No organism was found and […]

Inoperable Skin Cancers: Use of Vismodegib and Radiotherapy

mardi, août 19th, 2014

Basal Cell Carcinoma is know to be physiopathologically generated by an activation of the sonic hedgehog  pathway. Vismodegib is an inhibitor of smoothened (SMO*) and is proposed as an adjuvant therapy before radiotherapy here after a successful case report: it was used as a therapy for basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) […]

Etanercept-induced Lichen Striatus

mardi, août 19th, 2014

Lichen Striatus is a dermatosis along Blaschko lines and its etiology is unknown. It would occurr secondarily to a cytotoxic reaction because of a stimulation of the immune system. The authors report lichen striatus occurring after etanercept (50mg/d) in a 70 year old patient treated for rheumatoid arthritis. For full access to the free article […]

Acne Treatment: combine isotretinoin with an antihistamine to enhance results and reduce side-effects

mardi, août 12th, 2014

Isotretinoin remains the gold standard in the treatment of Acne Vulgaris especially since tolerable doses nowadays focus on low doses. However, even with this, patients can have difficulty tolerating them because of the occurrence of side effects such as xerosis of the skin and mucous membranes. Also, even here, isotretinoin can have adverse effect on […]

Dengue Fever and the skin

vendredi, août 8th, 2014

Up to 100 million individuals may be infected by the dengue virus each year. The virus is transmitted through arthropod bites (usually mosquitoes). Population increase makes control of mosquito population difficult as breeding sites (stagnant waters) are more numerous and less detectable (roofs…). Infection ranges from asymptomatic infection to dengue fever with/without hemorrhagic fever and […]

Psoriasis treatment: infection risk with biologics

vendredi, août 8th, 2014

Newer treatments against psoriasis are targeted and are called „biologics“ as a group. However biologics can be divided into two groups, based on their molecular target. The newer ones target Il-17 and include secukinumab. The « older » ones include etanercept, infliximab and adalimumab (which bind tumor necrosis factor (TNF)) Anti-TNF medication is known to carry a […]

Cannabis to treat Acne ?

lundi, août 4th, 2014

The authors sought to measure the effects of Cannabis sativa, (-)-cannabidiol (CBD) (a recreational drug) Results of the study show that: administration of CBD to cultured human sebocytes (cells that secrete sebum) and human skin organ culture inhibited the lipogenic actions of various compounds, including including testosterone. CBD suppresses sebocyte proliferation via the activation of […]

Mole checks and Melanoma detection

samedi, août 2nd, 2014

Strategies for early melanoma detection: Approaches to the patient with nevi. Goodson AG, Grossman D. J Am Acad Dermatol. 2009 May;60(5):719-35; quiz 736-8. doi: 10.1016/j.jaad.2008.10.065. Mole checks are the “bread and butter” of many dermatologists. The article summarizes the concepts of practical situations that arise when checking the skin or moles for melanoma: Should we […]

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