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4-n-butylresorcinol (4NB) in the treatment of pigment disorders (For Professionals)
Friday, September 28th, 2012The authors seek to measure the effet of 4-n-butylresorcinol to treat pigmented spots by comparing it with hydroquinone, arbutin and kojic acid. Hypothesis: Tyrosinase is the enzyme enabling the production of melanin. Many studies only investiage tyrosinase in mushrooms and mice melanoma cells These substances are not necessarily inhibitors of human tyrosinase Study Comparison of […]
Hyperpigmentary Disorders in Caucasians (For Professionals)
Friday, September 28th, 2012The following conditions can be found in the Caucasian population (non-exhaustive list): Freckles (Ephelides): increased amount of melanin with normal number of melanocytes lentigenes (solar lentigo): appear after 50 years old. Histologically: epidermal pigmentation located mainly in the basal layer Caused by an increase number of melanocytes (containing a normal amount of melanin) Solar hyperpigmentation: […]
Hyperhidrosis: Systemic Treatment (For Professionnals)
Friday, September 28th, 2012Systemic therapy for primary hyperhidrosis: a retrospective study of 59 patients treated with glycopyrrolate or clonidine. Walling HW. J Am Acad Dermatol. 2012 Mar;66(3):387-92. Epub 2011 Aug 4. Hyperhidrosis is a socially bothersome and psychologically devastating condition which occurs spontaneously, but can reach extreme proportions in hot and humid wethaer conditions. Treatment options appear to […]
Cysteamine Cream as a new skin depigmenting product
Friday, September 28th, 2012Presented at the Scientific Meeting: European Academy of Dermatology (EADV), Annual Meeting. Prague (Praha), Czech Republic (Česká republika, Česko), 27 – 30 September 2012 Hsu.C. 1, Pourahmadi M.2, Ahmadi S. 2, Ali Mahdi H. 3 1:Centre Medical du Lignon, Geneva, Switzerland. 2: Jahrom University Medical school, Jahrom, Iran. 3: Global Dermatology Information Portal. Royal Bahrain […]
Differentiating Psoriasis From Seborrheic Dermatitis (Seborrhoeic Dermatitis) (For Professionals)
Thursday, September 27th, 2012This is particularly useful when the diagnosis is not obvious from clinical examination* (nails, extensor surfaces (elbows), folds on the face): Psoriasis lesions appear reddish Seborrheic Dermatitis (Seborrhoeic Dermatitis) lesions appear yellowish *It is typical to have this problem when the lesions are located on the scalp only Use a dermatoscope and look at the […]
Are the newer non-Hydroquinone-based creams effective in treating melasma (chloasma, pregnancy mask) ? (For Profesionnals)
Thursday, September 27th, 2012The new generation (that is non-hydroquinone based) depigmentation creams also work… They are not as a group more effective than hydroquinone-based topicals(HQ)… …However they do have a much lower frequency and severity of side-effects Contributors: Dr Christophe HSU – dermatologist. Geneva, Switzerland Source of Information: 2012 (09) – Sachdev M. 21st Annual Congress of the […]
Are hormones involved in the pathogenesis of melasma (chloasma, pregnancy mask) ? (For Professionals)
Thursday, September 27th, 2012Hormones only provide a partial explanation to the pathogenesis of melasma (chloasma, mask of pregnancy) In a study involving 400 pregnant women: 16% of them had melasma even though it was not related to the stage of pregnancy Also the pigmentation was located more often on the arms which is an atypical distribution for melasma. […]
Are lasers effective in the treatment of melasma (chloasma, pregnancy mask) ? (For Professionals)
Thursday, September 27th, 2012Other articles deal with this issue however we can say here that lasers play a limited role: They are only indicated in the treatment of dermal melasma (chloasma, pregnancy mask). Even in this indication, the response is unpredictable* and the pigmentation tends to recur. Response to treatment has been reported for the following lasers (non-exhaustive […]
Is oral tranexamic acid effective in the treatment of melasma (chloasma, pregnancy mask) ? (For Professionals)
Thursday, September 27th, 2012Tranexamic acid is an antifibrinolytic which inhibits the conversion of plasminogen to plasmin. It has an antiallergic and antiinflammatory action. It might be effective in the treatment of melasma (chloasma, pregnancy mask): However tranexamic acid is in its inital stages and over the long run, the good results in the few reports* might not be […]
Is Hydroquinone (HQ) safe ? (For professionals)
Thursday, September 27th, 2012Hydroquinone is the Gold Standard for treating Melasma (Chloasma, Pregnancy Mask). Numerous concentrations are used but a concentration of 4% in practice begins to be effective (and to have side-effects). Side effects include: erythema burning exogenous ochronosis confetti-like depigmentation In practice it is safe to use at 4% when closely supervised medically. Contributors: Dr Christophe […]
