Section : Conference Notes

Hydroquinone toxicity

Short term and long term issues are described

Short-term: Exogenous ochronosis.

  • It is a possible side effect from prolonged use of hydroquinone, especially at concentrations higher than 4%
  • It has also been described for resorcinol, phenols (such as rhododenol), oral antimalarials.
  • It is due to inhibition of homogentisic acid by hydroquinone.
  • On histology, the following features are seen:
    • collagen degeneration
    • “banana-like” figures (intensely eosinophilic)
    • elastosis
    • pigment incontinence

Long-term: carcinogenicty

  • In rats studies report a higher incidence of nephrogenic adenomas and soft cell tumors (leukemia)
  • This effect has NOT been observed in humans
  • As a precautionary measure, regulatory jurisdictions such as the European Union have been banned these agents in the “Over-the-counter” market and can only be prescribed by a doctor.

Source of information: Verma S. Hydroquinone revisited. European Academy of Dermatology and Venereology (EADV) Annual Meeting – Istanbul, Turkey, 2-6 October 2013

Category : Hydroquinone toxicity - Modifie le 10.10.2013Category : Toxicité de l'Hydroquinone - Modifie le 10.10.2013