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Hori’s Nevus (Bilateral Acquired Nevus of Ota)
Sunday, June 10th, 2012Introduction It is a skin disorder which concerns mainly Asians Clinically, Hori’s Nevus can coexist with melasma (chloasma, pregnancy mask) and or solar lentigos. It can be difficult to distinguish them*. *But it is important to distinguish them as Hori’s nevus responds well to the Nd-YAG 1064nm laser. However, solar lentigos (lentigenes) respond well to […]
Lignin Peroxidase: a cosmeceutical to treat hyperpigmentation
Saturday, June 9th, 2012Hyperpigmentation disorders are diverse and treatment success is highly variable. However it is important to note that the more superficial the pigmentation is, the better the response to treatment is likely to be high. Here below is a proposed skin lightening agent: lignin peroxidase It is derived from a fungus: phanerochaete chrysosporium It was studied […]
Hydroquinone To Treat Post-Inflammatory Hyperpigmentation Caused By Acne Vulgaris
Friday, June 1st, 2012Hydroquinone Therapy for Post-inflammatory Hyperpigmentation Secondary to Acne: Not Just Prescribable by Dermatologists. Chandra M, Levitt J, Pensabene CA. Acta Derm Venereol. 2011 Oct 17. doi: 10.2340/00015555-1225. In darker skin phototypes (Fitzpatrick IV and above), post inflammatory hyperpigmentation (PIH) following active inflammatory acne lesions (papules, pustules) is an issue and very common cause of emotional […]
Skin Manifestations in Anaphylaxis (For Professionals)
Wednesday, May 16th, 2012Anaphylaxis is a severe form of allergic reaction to certain substances such as food, drugs, insect stings and others. These substances serve as stimuli which attract certain antibodies in the body known as IgE antibodies. These IgE antibodies are bound to mast cells in the skin. These mast cells release chemicals that are disseminated in […]
Using Hydroquinone and Ochronosis
Wednesday, May 16th, 2012Rule No: 1 Recognize melasma (chloasma, pregnancy mask) Rule out the differential diagnoses: lichen planus pigmentosus (darker skin patients (Indians), pigmentation is often seen behind the ears) Hori’s Nevus Drug-induced hyperpigmentation ochronosis Rule No: 2 If the patient reports worsening of melasma with hydroquinone use, consider seriouslsy the diagnosis of ochronosis: Stage 3 ochronosis is […]
Hyperpigmentary Disorders in Children
Sunday, May 13th, 2012Pigmentary disorders are frequent in children and can result in significant psychosocial problems. Hyperpigmentary disorders can be classified into melanocytes problems (epidermal, dermal) and neurocutaneous disorders presenting with pigmentation problems. Giant congenital nevus carries a low risk of malignant transformation (melanoma) but it is important to exclude cutaneous neuromelanosis in high risk patients. Malignant lentiginosis […]
Synthesis of Melanin and its Disturbances
Sunday, May 13th, 2012Melanin is produced by mature melanocytes. The biosynthesis of melanin is a complex which implicateds numerous enzymes which include tyrosinase, TRP1, TRP2…Genetic disturbances of these enzymes can result in a pigmentary dilution which translates clinically with depigmentation as is seen for example in oculocutaneous albinism. The production of melanin is done within melanocytes in organelles […]
The Role of Keratinocytes in Disorders of Pigmentation
Sunday, May 13th, 2012From the extremities of dendritic melanocytes, melanosomes are transfered to the neighbouring keratinocytes. However, the mechanisms implicated in this transfer are not well understood but involve an intimate contact between a melanocyte and a keratinocyte (in the epidermis). This in turn implies the presence of cell membrane proteins. The incapacity to do this explains the […]
Hypopigmentary Disorders in Children
Sunday, May 13th, 2012Pigmentary disorders are frequent in children and can result in significant psychosocial problems. Hypopigmentary disorders may be caused by absence or reduction of the number of melanocytes. They can also be caused by the reduction or absence of production of melanin (with a normal number of melanocytes). Vitligo is a skin disorder which is clinically […]
Oral Tranexamic Acid in the Treatment of Melasma (Chloasma, Pregnancy mask): a Summary
Sunday, May 13th, 2012Oral tranexamic acid taken orally is effective in the treatment of melasma (chloasma, pregnancy mask) refractory to topical combination treatment. These results are supported by evidence from previous studies frm Japan and South Korea. Tranexamic Acid (trans-4-aminomethylcyclohexanecarboxylic acid) is an anti-fibrinolytic agent which inhibits the activation of plasminogen by reversible blockade of lysine-binding molecules on […]
